Daxsonics Affiliates at IEEE Ultrasonics: Real-Time Imaging, Targeting, and Ablation of Ex-Vivo Tissue Using a Handheld Histotripsy Transducer

Jeffrey Woodacre*, Thomas Landry, Jeremy Brown
Department of Biomedical Engineering Dalhousie University
Halifax, Nova Scotia, Can
ada Corresponding Author*: jwoodacr@dal.ca

Abstract—. In this work, we have developed a small, handheld histotripsy transducer where the ablation focus is imaged in real- time using a co-registered 45 MHz 64-element phased array endoscope. The construction of a 2 cm diameter, 40% volume fraction, strongly curved, PZT5A composite transducer capable of generating cavitation within tissue is outlined. The co- registered imaging and ablation tool was able to ablate a 1 mm x 0.5 mm x 0.5 mm volume below the surface of a chinchilla brain using a single 5 second, 1 kHz PRF, 10 cycle burst, without damage to the surface leading to the ablation site. Total electrical power draw during treatment was less than 4 W.